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The active chemical compound tetrahydrocannabinol (THC) is a psychoactive substance found in cannabis.
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THC has analgesic effects that, even at low doses, causes a "high", thus leading to the fact that medical cannabis can be used to treat pain. The mechanism for analgesic effects caused directly by THC or other cannabinoid agonists is not fully elucidated. Other effects include: relaxation; euphoria; altered space-time perception; alteration of visual, auditory, and olfactory senses; disorientation; fatigue; and appetite stimulation related to CB1 receptor activity in the central nervous system. The mechanism for appetite stimulation in subjects is somewhat understood and explained through a gastro-hypothalamic axis. CB1 activity in the hunger centres in the hypothalamus that increase the palatability of food, a hunger hormone--ghrelin increases hunger signals as food enters the stomach. After chyme is passed into the duodenum, signaling hormones such as CCK and leptin are released causing reduction in gastric emptying and satiety signals to the hypothalamus, respectively. Cannabinoid activity is reduced through the satiety signals induced by leptin release. It also has anti-emetic properties, and also may reduce aggression in certain subjects.
